This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by García de Viedma, D. Articles by Sola, C. Search for Related Content PubMed PubMed Citation Articles by García de Viedma, D. Articles by Sola, C.

Analysis of Mycobacterium tuberculosis Genotypes in Madrid and Identification of Two New Families Specific to Spain-Related Settings

Department of Clinical Microbiology and Infectious Diseases, Gregorio Marañón Hospital, Madrid, Spain,¹ Unité de la Tuberculose et des Mycobactéries, Institut Pasteur de Guadeloupe, Pointe-à-Pitre, Guadeloupe²

Received 2 July 2004/ Returned for modification 21 September 2004/ Accepted 25 October 2004

In Spain, tuberculosis (TB) patterns are changing because of the recent increase in the number of cases among immigrants. To establish the composition of circulating Mycobacterium tuberculosis strains before the effects of foreign strains appear, this study focused on molecular characterization of 233 patient isolates using spoligotyping. The spoligotyping data were further analyzed using an international database, SpolDB4. The results obtained showed that the general features of the M. tuberculosis population in Spain are coherent with those of other European countries, with the Latin American and Mediterranean group, and with the Haarlem 3 and T1 families as the most prevalent genotypes. The Spanish isolates clustered mostly with genotypes which had previously been isolated in countries linked with Spain. We also describe and fully characterize two novel M. tuberculosis families, Madrid1 and Madrid2, which are specific to Spain-related settings. The data reported here provide a solid reference when monitoring changes in the composition of the M. tuberculosis population in Spain as a consequence of the increasing rate of TB in the foreign population.

This article has been cited by other articles:

• Streicher, E. M., Victor, T. C., van der Spuy, G., Sola, C., Rastogi, N., van Helden, P. D., Warren, R. M. (2007). Spoligotype Signatures in the Mycobacterium tuberculosis Complex. J. Clin. Microbiol. 45: 237-240 [Abstract] [Full Text]