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Journal of Clinical Microbiology, April 2005, p. 1928-1929, Vol. 43, No. 4
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.4.1928-1929.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Misidentification of Mycobacterium leprae as Mycobacterium intracellulare by the COBAS AMPLICOR M. intracellulare Test

M. Lefmann,1,2* A. Moter,1 B. Schweickert,1 and U. B. Göbel1

Institut für Mikrobiologie und Hygiene, Campus Charité Mitte, Charité—Universitätsmedizin Berlin ,1 Institut für Medizinische Mikrobiologie am HELIOS-Klinikum Berlin-Buch, HAEMA AG Berlin, Germany2

Received 2 August 2004/ Returned for modification 10 September 2004/ Accepted 5 December 2004

Commercially available nucleic acid probe- and amplification-based systems for detection and differentiation of mycobacteria are widely used in clinical microbiology laboratories. Here we report two cases of human leprosy in which the COBAS AMPLICOR Mycobacterium intracellulare test led to false- positive results. Correct identification of Mycobacterium leprae was possible only by amplification and comparative sequence analysis of the 16S rRNA gene.

* Corresponding author. Mailing address: Institut für Medizinische Mikrobiologie am HELIOS-Klinikum Berlin-Buch, HAEMA AG, Wiltbergstr. 50, 13125 Berlin, Germany. Phone: 49-30-9401-2328. Fax: 49-30-9401-4324. E-mail: mlefmann{at}berlin.helios-kliniken.de.

Journal of Clinical Microbiology, April 2005, p. 1928-1929, Vol. 43, No. 4
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.4.1928-1929.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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