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Journal of Clinical Microbiology, April 2005, p. 2002-2003, Vol. 43, No. 4
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.4.2002-2003.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Long-Lasting CD3+ T-Cell Deficiency after Cord Blood Stem Cell Transplantation in a Human Herpesvirus 6-Infected Child

Manola Comar,1 Pierlanfranco D'Agaro,1 Douglas Horejsh,2 Monica Galvan,3 Simona Fiorentini,2 Marino Andolina,4 Arnaldo Caruso,2 Dario Di Luca,3 and Cesare Campello1*

Department of Public Medicine Sciences, University of Trieste,1 Bone Marrow Transplantation Unit, I.R.C.C.S. "Burlo Garofolo," Trieste,4 Institute of Microbiology, University of Brescia, Brescia,2 Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy3

Received 29 September 2004/ Returned for modification 8 November 2004/ Accepted 1 December 2004

We report a long-lasting (8-month) reactivation of human herpesvirus 6 (HHV-6) infection in child who had undergone cord blood stem cell transplantation. The reactivation was characterized by high viral loads and by immediate-early mRNA positivity. HHV-6 infection was associated with a deep depletion of CD3, while the CD4/CD8 ratio remained substantially unchanged.

* Corresponding author. Mailing address: IRCCS "Burlo Garofolo," Via dell'Istria 65/1, 34137 Trieste, Italy. Phone: 39 040 3785355. Fax: 39 040 3785210. E-mail: campello{at}burlo.trieste.it.

Journal of Clinical Microbiology, April 2005, p. 2002-2003, Vol. 43, No. 4
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.4.2002-2003.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Comar, M, D'Agaro, P, Campello, C, Poli, A, Breinholt, J P III, Towbin, J A, Vatta, M (2009). Human herpes virus 6 in archival cardiac tissues from children with idiopathic dilated cardiomyopathy or congenital heart disease. J. Clin. Pathol. 62: 80-83 [Abstract] [Full Text]  
  • Sullivan, B. M., Coscoy, L. (2008). Downregulation of the T-Cell Receptor Complex and Impairment of T-Cell Activation by Human Herpesvirus 6 U24 Protein. J. Virol. 82: 602-608 [Abstract] [Full Text]  


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