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Journal of Clinical Microbiology, April 2005, p. 2012-2014, Vol. 43, No. 4
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.4.2012-2014.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Surgery and Treatment with High-Dose Liposomal Amphotericin B for Eradication of Craniofacial Zygomycosis in a Patient with Hodgkin's Disease Who Had Undergone Allogeneic Hematopoietic Stem Cell Transplantation

Michelle A. Barron,* Margaret Lay, and Nancy E. Madinger

University of Colorado Health Sciences Center, Denver, Colorado

Received 18 October 2004/ Returned for modification 20 November 2004/ Accepted 9 December 2004

This case report describes craniofacial zygomycosis in a 24-year-old male with Hodgkin's disease who underwent chemotherapy and autologous hematopoietic stem cell transplantation, followed by a nonmyeloablative allogeneic transplant. Empirical therapy with itraconazole and amoxicillin-clavulanate failed to resolve the infection. Postdiagnosis, surgery and treatment with high-dose liposomal amphotericin B eradicated the disease.

* Corresponding author. Mailing address: University of Colorado Health Sciences Center, 4200 E. Ninth Avenue, Box 168, Denver, CO 80262. Phone: (303) 315-1113. Fax: (303) 315-8681. E-mail: Michelle.Barron{at}UCHSC.edu.

Journal of Clinical Microbiology, April 2005, p. 2012-2014, Vol. 43, No. 4
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.4.2012-2014.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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