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Journal of Clinical Microbiology, May 2005, p. 2441-2443, Vol. 43, No. 5
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.5.2441-2443.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Interrelationship between Polymorphisms of incA, Fusogenic Properties of Chlamydia trachomatis Strains, and Clinical Manifestations in Patients in The Netherlands

Yvonne Pannekoek,1* Joke Spaargaren,2 Ankie A. J. Langerak,1 Judith Merks,2 Servaas A. Morré,3 and Arie van der Ende1

Academic Medical Center, Department of Medical Microbiology, University of Amsterdam, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands,1 Public Health Laboratory, Municipal Health Service of Amsterdam, Amsterdam, The Netherlands,2 Laboratory of Immunogenetics, Section Immunogenetics of Infectious Diseases, VU University Medical Centre, Amsterdam, The Netherlands3

Received 16 July 2004/ Returned for modification 7 October 2004/ Accepted 17 January 2005

IncA variation among Dutch Chlamydia trachomatis isolates was investigated. Of 98 strains, two carried an incA with a premature stop codon, lacked IncA, and were nonfusogenic, while 96 contained an intact incA, expressed IncA, and were fusogenic. Among these 96 strains, nine IncA sequence types were found, of which the three most frequently encountered (88% of the strains) were randomly distributed among symptomatic and asymptomatic patients.


* Corresponding author. Mailing address: Dept. of Medical Microbiology, Academic Medical Center, University of Amsterdam, Room L1-115, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. Phone: 31 20 5664862. Fax: 31 20 6979271. E-mail: y.pannekoek{at}amc.uva.nl.


Journal of Clinical Microbiology, May 2005, p. 2441-2443, Vol. 43, No. 5
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.5.2441-2443.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.