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Journal of Clinical Microbiology, May 2005, p. 2510-2512, Vol. 43, No. 5
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.5.2510-2512.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Streptococcus pneumoniae Antigen Test Using Positive Blood Culture Bottles as an Alternative Method To Diagnose Pneumococcal Bacteremia

Clinical Microbiology Laboratory, Duke University Medical Center, and Departments of Pathology and Medicine, Duke University School of Medicine, Durham, North Carolina 27710

Received 24 June 2004/ Returned for modification 14 September 2004/ Accepted 28 January 2005

Recovery of Streptococcus pneumoniae from positive blood culture bottles may be difficult due to autolysis of pneumococci. Therefore, we evaluated the performance of the Binax NOW S. pneumoniae antigen test with samples from positive blood culture bottles and defined the duration of detectable pneumococcal antigen in these bottles. Use of the S. pneumoniae antigen test is an alternative method for identifying S. pneumoniae from positive blood culture bottles and may enable a diagnosis of pneumococcal bacteremia despite negative subcultures.

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