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Journal of Clinical Microbiology, June 2005, p. 2635-2641, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2635-2641.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

High Frequency of Gastric Colonization with Multiple Helicobacter pylori Strains in Venezuelan Subjects

C. Ghose,1 G. I. Perez-Perez,1* L. J. van Doorn,2 M. G. Domínguez-Bello,3 and M. J. Blaser1,4

Departments of Microbiology and Medicine, New York University School of Medicine, New York, New York,1 Delft Diagnostic Laboratories, Delft, The Netherlands,2 Laboratory of Gastrointestinal Physiology, IVIC, Caracas, Venezuela,3 Department of Veterans Affairs Medical Center, New York, New York4

Received 29 November 2004/ Returned for modification 22 December 2004/ Accepted 17 February 2005

Multiple Helicobacter pylori strains may colonize an individual host. Using enzyme-linked immunosorbent assay and line probe assay (LiPA) techniques, we analyzed the prevalence of mixed H. pylori colonization in 127 subjects from Venezuela, a country of high H. pylori prevalence, from three regions representing different population groups: the Andes (Merida), where Caucasian mestizos predominate, a major city near the coast (Caracas), where Amerindian-Caucasian-African mestizos predominate, and an Amazonian community (Puerto Ayacucho), where Amerindians predominate and mestizos reflect Amerindian and Caucasian ancestry. Among 121 H. pylori-positive persons, the prevalence of cagA-positive strains varied from 50% (Merida) to 86% (Puerto Ayacucho) by LiPA. Rates of mixed colonization also varied, as assessed by LiPA of the vacA s (mean, 49%) and m (mean, 26%) regions. In total, 55% of the individuals had genotypic evidence of mixed colonization. vacA s1c, a marker of Amerindian (East Asian) origin, was present in all three populations, especially from Puerto Ayacucho (86%). These results demonstrate the high prevalence of mixed colonization and indicate that the H. pylori East Asian vacA genotype has survived in all three populations tested.

* Corresponding author. Mailing address: Infectious Diseases Laboratories, Department of Medicine, VAMC 6026 West, 423 East 23rd Street, New York, NY 10010. Phone: (212) 263-4105. Fax: (212) 263-4108. E-mail: perezg02{at}med.nyu.edu.

Journal of Clinical Microbiology, June 2005, p. 2635-2641, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2635-2641.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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