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Journal of Clinical Microbiology, June 2005, p. 2929-2931, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2929-2931.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Cryptococcus neoformans Galactoxylomannan Contains an Epitope(s) That Is Cross-Reactive with Aspergillus Galactomannan

Frédéric Dalle,1 Pierre Emmanuel Charles,2 Karine Blanc,1 Denis Caillot,3 Pascal Chavanet,2 Françoise Dromer,4 and Alain Bonnin1*

Laboratoire de Parasitologie Mycologie, CHU, Hôpital du Bocage, and Laboratoire de Microbiologie Médicale et Moléculaire, Faculté de Médecine, Dijon, France,1 Service des Maladies Infectieuses et Tropicales, CHU, Hôpital d'enfants, and Laboratoire de Microbiologie Médicale et Moléculaire, Faculté de Médecine, Dijon, France,2 Service d'Hématologie Clinique, CHU, Hôpital d'enfants, Dijon, France,3 Centre National de Référence de la Mycologie et des Antifongiques, Institut Pasteur, Paris, France4

Received 10 November 2004/ Returned for modification 7 December 2004/ Accepted 25 January 2005

We report a case of cryptococcosis in which a serum enzyme-linked immunosorbent assay (ELISA) for Aspergillus galactomannan was positive, with no evidence of aspergillosis. Soluble antigens from 19 Cryptococcus neoformans strains and purified carbohydrates of C. neoformans capsule were thus assayed in the Aspergillus galactomannan ELISA. Antigens from all C. neoformans strains, and purified galactoxylomannan, gave a positive reaction, suggesting that C. neoformans galactoxylomannan contains an epitope(s) that is cross-reactive with Aspergillus galactomannan.

* Corresponding author. Mailing address: Laboratoire de Parasitologie Mycologie, Hôpital du Bocage, BP 77 908, 21079 Dijon Cedex, France. Phone: 33 (0)380 29 36 03. Fax: 33 (0)380 29 32 80. E-mail: alain.bonnin{at}chu-dijon.fr.

Journal of Clinical Microbiology, June 2005, p. 2929-2931, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2929-2931.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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