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Journal of Clinical Microbiology, June 2005, p. 2965-2968, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2965-2968.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Occurrence of hlyA and sheA Genes in Extraintestinal Escherichia coli Strains

Monika Kerényi,1* Heather E. Allison,2 István Bátai,3 Ágnes Sonnevend,4 Levente Emödy,1 Nóra Plaveczky,1 and Tibor Pál1,4

Departments of Medical Microbiology and Immunology,1 Anesthesiology and Intensive Therapy, Medical School, University of Pécs, Hungary,3 School of Biological Sciences, Division of Microbiology and Genomics, University of Liverpool, Liverpool, United Kingdom,2 Department of Medical Microbiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain 17666, United Arab Emirates4

Received 10 August 2004/ Returned for modification 3 September 2004/ Accepted 3 February 2005

The association of a hemolytic phenotype with the carriage of the {alpha}-hemolysin gene (hlyA) and/or the silent hemolysin gene (sheA or clyA) among 540 extraintestinal clinical isolates of Escherichia coli and 110 fecal isolates from healthy individuals was investigated. Though HlyA is an important virulence factor in extraintestinal E. coli infection, the role of SheA is not completely clarified. Two hemolytic sheA+ E. coli strains that lacked hlyA and possessed no other hemolysin genes were identified. No hlyA+ sheA+ strains were identified, suggesting that there is possible incompatibility between hlyA and sheA in the chromosome of E. coli.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Pécs, Szigeti u. 12. H-7624, Hungary. Phone: 36 72 536001. Fax: 36 72 536253. E-mail: monika.kerenyi{at}aok.pte.hu.

Journal of Clinical Microbiology, June 2005, p. 2965-2968, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2965-2968.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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