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Journal of Clinical Microbiology, June 2005, p. 2980-2983, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2980-2983.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Demonstration of a High Level of Parasite Population Homology by Quantification of Plasmodium falciparum Alleles in Matched Peripheral, Placental, and Umbilical Cord Blood Samples

Sayeh Jafari-Guemouri,1,{dagger} Nicaise Tuikue Ndam,1,{dagger} Gwladys Bertin,1 Emily Renart,1 Sokhna Sow,2 Jean-Yves Le Hesran,3 and Philippe Deloron1*

Faculté de Pharmacie, UR 010, Mother and Child Health in the Tropics, Institut de Recherche pour le Développement (IRD), 75006 Paris, France,1 Hôpital de Thiadiaye, Sénégal,2 UR 010, Mother and Child Health in the Tropics, Institut de Recherche pour le Développement (IRD), BP1386, CP18524 Dakar, Sénégal3

Received 27 September 2004/ Returned for modification 14 November 2004/ Accepted 29 January 2005

Plasmodium falciparum msp-1 and msp-2 genes were quantified by fragment analysis in matched placental, peripheral, and cord blood samples. In the three compartments, the multiplicity of infection values were similar, and parasite populations only partially overlapped, as reported. However, identical alleles represented 80 to 95% of the overall parasite populations of each compartment, demonstrating much more homogenous parasite populations than previously thought.

* Corresponding author. Mailing address: Institut de Recherche pour le Développement, UR010, Paris, France. Phone: 33 1 53 73 96 22. Fax: 33 1 53 73 96 17. E-mail: Philippe.Deloron{at}ird.fr.

{dagger} S.J.-G. and N.T.N. contributed equally to this work.

Journal of Clinical Microbiology, June 2005, p. 2980-2983, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2980-2983.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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