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Journal of Clinical Microbiology, June 2005, p. 2989-2990, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2989-2990.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Cryptococcal Antigen Test Revisited: Significance for Cryptococcal Meningitis Therapy Monitoring in a Tertiary Chinese Hospital

Hongzhou Lu,1,2* Yingjie Zhou,1 Youkuan Yin,1 Xiaozhang Pan,1 and Xinhua Weng1

Department of Infectious Diseases, Fudan University Huashan Hospital, Shanghai 200040,1 Shanghai Public Health Center, Shanghai 201508, People's Republic of China2

Received 26 November 2004/ Returned for modification 4 January 2005/ Accepted 7 February 2005

For a total of 29 non-human immunodeficiency virus 1 cryptococcal meningitis cases, titer changes in the latex agglutination test before and after therapy were reviewed along with clinical manifestations, laboratory findings, and therapy regimens. The cryptococcal antigen titer decreased for every case after therapy and was correlated to fungal clearance as defined by fungus smear and/or culture. However, cryptococcal antigen can remain at low titers for long periods of time after therapy, even when fungus smears and/or cultures become negative.

* Corresponding author. Mailing address: Department of Infectious Diseases, Fudan University Huashan Hospital, 12 Wulumuqi Zhong Road, Shanghai 200040, People's Republic of China. Phone: 86 21 6248 9999. Fax: 86 21 6248 9015. E-mail: luhongzhou66{at}hotmail.com.

Journal of Clinical Microbiology, June 2005, p. 2989-2990, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.2989-2990.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Satpute, M. G., Telang, N. V., Litake, G. M., Niphadkar, K. B., Joshi, S. G. (2006). Prevalence of cryptococcal meningitis at a tertiary care centre in Western India (1996-2005).. J Med Microbiol 55: 1301-1302 [Full Text]  
  • Antinori, S., Radice, A., Galimberti, L., Magni, C., Fasan, M., Parravicini, C. (2005). The Role of Cryptococcal Antigen Assay in Diagnosis and Monitoring of Cryptococcal Meningitis. J. Clin. Microbiol. 43: 5828-5829 [Full Text]  


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