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Journal of Clinical Microbiology, June 2005, p. 3003-3006, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.3003-3006.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Inability To Make a Premortem Diagnosis of Acanthamoeba Species Infection in a Patient with Fatal Granulomatous Amebic Encephalitis

Karen C. Bloch1* and Frederick L. Schuster2

Departments of Medicine and Preventive Medicine, Vanderbilt University, Nashville, Tennessee,1 California Department of Health Services, Richmond, California2

Received 5 November 2004/ Returned for modification 7 January 2005/ Accepted 20 January 2005

Granulomatous amebic encephalitis (GAE), an infection of immunocompromised hosts, is almost uniformly fatal. A case of GAE in a patient who failed to mount a serologic response to Acanthamoeba polyphaga is presented. Although Acanthamoeba polyphaga that is sensitive to multiple antimicrobials grew from brain tissue, an inability to make a premortem diagnosis precluded therapy.

* Corresponding author. Mailing address: Division of Infectious Diseases, A-2200 MCN, Vanderbilt University, Nashville, TN 37232-2605. Phone: (615) 322-2035. Fax: (615) 343-6160. E-mail: Karen.bloch{at}vanderbilt.edu.

Journal of Clinical Microbiology, June 2005, p. 3003-3006, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.3003-3006.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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