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Journal of Clinical Microbiology, June 2005, p. 3014-3016, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.3014-3016.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Atypical Serological Response Marked by a Lack of Detectable Anti-gp43 Antibodies in a Patient with Disseminated Paracoccidioidomycosis

Mônica S. M. Vidal,1*,{dagger} Gil Benard,2,{dagger} Thales de Brito,3 Kátia C. Dantas,1 Cristiane N. Pereira,1 Francisco O. S. França, Ana M. G. da Silva,3 and José E. C. Martins1

Laboratories of Medical Mycology,1 Dermatology and Immunodeficiencies,2 Immunopathology, Institute of Tropical Medicine, Medical School of the University of São Paulo, Brazil,3 Division of Infectious and Parasitic Diseases, Clinics Hospital, Medical School of the University of São Paulo, Brazil4

Received 12 November 2004/ Returned for modification 15 December 2004/ Accepted 17 December 2004

Serological tests are frequently used to diagnosis paracoccidioidomycosis. A glycoprotein of 43 kDa is considered to be the main diagnostic antigen, being recognized by virtually all patients' sera. A case of atypical serological response, consisting of a lack of detectable anti-gp43 antibodies, in a patient with disseminated paracoccidioidomycosis is presented.

* Corresponding author. Mailing address: Instituto de Medicina Tropical de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 500, andar térreo, CEP:05403-000, São Paulo, SP, Brazil. Phone: 55 11 30667046. Fax: 55 11 30817190. E-mail: movida{at}usp.br.

{dagger} M.S.M.V. and G.B. contributed equally to this work.

Journal of Clinical Microbiology, June 2005, p. 3014-3016, Vol. 43, No. 6
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.6.3014-3016.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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