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Journal of Clinical Microbiology, July 2005, p. 3356-3363, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3356-3363.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

A Panton-Valentine Leucocidin (PVL)-Positive Community-Acquired Methicillin-Resistant Staphylococcus aureus (MRSA) Strain, Another Such Strain Carrying a Multiple-Drug Resistance Plasmid, and Other More-Typical PVL-Negative MRSA Strains Found in Japan

Yoko Takizawa,1 Ikue Taneike,1 Saori Nakagawa,1 Tomohiro Oishi,2 Yoshiyuki Nitahara,1 Nobuhiro Iwakura,1 Kyoko Ozaki,1 Misao Takano,1 Teruko Nakayama,1 and Tatsuo Yamamoto1*

Department of Infectious Disease Control and International Medicine, Division of Bacteriology, Niigata University Graduate School of Medical and Dental Sciences,1 Department of Pediatrics, Joetsu General Hospital, Niigata, Japan2

Received 29 August 2004/ Returned for modification 20 January 2005/ Accepted 29 March 2005

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) was collected from children with bullous impetigo in 2003 and 2004. One strain collected in 2003 was Panton-Valentine leucocidin (PVL) positive. In 2004, a multiple-drug-resistant PVL+ CA-MRSA strain was isolated from an athlete with a cutaneous abscess. These strains were analyzed by multilocus sequence typing, spa typing, agr typing, coagulase typing, staphylococcal cassette chromosome mec (SCCmec) typing, PCR assay for 30 virulence genes, drug susceptibility testing, pulsed-field gel electrophoresis, and for plasmids. The two Japanese PVL+ CA-MRSA strains belonged to the globally extant ("pandemic") sequence type 30 (ST30) with SCCmec IV. A transmissible, multiple-drug resistance plasmid emerged in such ST30 strains. The PVL– CA-MRSA strains ("domestic" CA-MRSA) accumulated for bullous impetigo, exhibiting new genotypes. Hospital-acquired MRSA of ST91 (but not pandemic ST5) shared common features with the PVL– CA-MRSA strain.

* Corresponding author. Mailing address: Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, 757 Ichibanchou, Asahimachidori, Niigata, Japan. Phone: 81 25 227 2050. Fax: 81 25 227 0762. E-mail: tatsuoy{at}med.niigata-u.ac.jp.

Journal of Clinical Microbiology, July 2005, p. 3356-3363, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3356-3363.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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