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Journal of Clinical Microbiology, July 2005, p. 3421-3426, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3421-3426.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Potential Secondary Pathogenic Role for Bovine Herpesvirus 4

Gaetano Donofrio,1* Sandro Cavirani,1 Vicky van Santen,2 and Cesidio Filippo Flammini1

Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali Facoltà di Medicina Veterinaria, via del Taglio 8, 43100 Parma, Italy,1 Department of Pathobiology, 264 Greene Hall, College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849-55192

Received 12 October 2004/ Returned for modification 14 January 2005/ Accepted 30 March 2005

Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus with no clear disease association. Previous studies have demonstrated that macrophages can harbor persistent BoHV-4. We found that the addition of prostaglandin E2 (PGE2) to bovine macrophage cells persistently infected with BoHV-4 increases viral replication. Because opportunistic infection can increase PGE2 production, we propose a link between opportunistic infection, PGE2 production, and BoHV-4 replication.

* Corresponding author. Mailing address: Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Facoltà di Medicina Veterinaria, via del Taglio 8, 43100 Parma, Italy. Phone: 39 0521 902669. Fax: 39 0521 902672. E-mail: gaetano.donofrio{at}unipr.it.

Journal of Clinical Microbiology, July 2005, p. 3421-3426, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3421-3426.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Donofrio, G., Herath, S., Sartori, C., Cavirani, S., Flammini, C. F., Sheldon, I. M. (2007). Bovine herpesvirus 4 is tropic for bovine endometrial cells and modulates endocrine function. Reproduction 134: 183-197 [Abstract] [Full Text]  


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