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Journal of Clinical Microbiology, July 2005, p. 3467-3470, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3467-3470.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Age-Related Prevalence and Distribution of Nontuberculous Mycobacterial Species among Patients with Cystic Fibrosis

Catherine Pierre-Audigier,1 Agnès Ferroni,1 Isabelle Sermet-Gaudelus,2 Muriel Le Bourgeois,2 Catherine Offredo,1 Hoang Vu-Thien,3 Brigitte Fauroux,4 Patricia Mariani,5 Anne Munck,6 Edouard Bingen,5 Didier Guillemot,7 Gilles Quesne,1 Véronique Vincent,8 Patrick Berche,1 and Jean-Louis Gaillard9*

Laboratoire de Microbiologie,1 Département de Pédiatrie, Hôpital Necker-Enfants Malades, Assistance Publique— Hôpitaux de Paris (AP-HP), 75015 Paris,2 Laboratoire de Microbiologie,3 Département de Pédiatrie, Hôpital Armand Trousseau, AP-HP, 75012 Paris,4 Laboratoire de Microbiologie,5 Département de Pédiatrie, Hôpital Robert Debré, AP-HP, 75019 Paris,6 Centre de Ressources en Biostatistiques, Epidémiologie et Pharmacoépidémiologie,7 Centre National de Référence des Mycobactéries, Institut Pasteur, 75015 Paris,8 Laboratoire de Microbiologie, Hôpital Raymond Poincaré, AP-HP, 92380 Garches, France9

Received 16 November 2004/ Returned for modification 20 January 2005/ Accepted 11 April 2005

We studied the prevalence and species distribution of nontuberculous mycobacteria (NTM) in relation to age in 385 patients with cystic fibrosis (CF) (mean age ± standard deviation [range], 12.0 ± 6.1 [1 to 24] years; sex ratio, 0.53) attending three Parisian centers. The overall prevalence of NTM in sputum was 8.1% (31 out of 385). The following NTM were isolated (n = 33): Mycobacterium abscessus (n = 13, 39.4%), Mycobacterium avium complex (MAC) (n = 7, 21.2%), Mycobacterium gordonae (n = 6, 18.2%), and other (n = 7, 21.2%). Sixteen patients met the American Thoracic Society microbiological criteria for NTM infection, including 11 patients positive for M. abscessus, 4 for MAC, and 1 for MAC and Mycobacterium kansasii. The overall prevalence of NTM was significantly lower in patients under 15 years old than for patients equal to or more than 15 years old (4.8 versus 14.9%, respectively; P = 0.001). M. abscessus was isolated at all ages, while MAC was not recovered before 15 years (prevalence of 0.0 and 5.2% in patients aged 1 to 14 and 15 to 24, respectively; P = 0.001).

* Corresponding author. Mailing address: Laboratoire de Microbiologie, Hôpital Raymond Poincaré, 104 Boulevard Raymond Poincaré, 92380, Garches, France. Phone: 33 1 47 10 79 50. Fax: 33 1 47 10 79 49. Email: jean-louis.gaillard{at}rpc.ap-hop-paris.fr.

Journal of Clinical Microbiology, July 2005, p. 3467-3470, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3467-3470.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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