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Journal of Clinical Microbiology, July 2005, p. 3508-3511, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3508-3511.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Identification of Unique Bacterial Gene Segments from Streptococcus mutans with Potential Relevance to Dental Caries by Subtraction DNA Hybridization

Division of Diagnostics, Infectious Disease, and Health Promotion,¹ Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York 10010²

Received 10 February 2005/ Returned for modification 22 February 2005/ Accepted 24 March 2005

Using DNA subtractive hybridization, 49 unique gene segments were identified from a strain of Streptococcus mutans that was isolated from a patient with severe early childhood caries (S-ECC). Further hybridization with DNA from other S. mutans strains isolated from both caries-active and caries-free subjects yielded five unique sequences of DNA common to strains associated with S-ECC.

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