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First Infection with VanD-Type Glycopeptide-Resistant Enterococcus faecium in Europe

Laboratoire Universitaire d'Antibiologie, Faculté de Médecine, Avenue Kennedy, 30900 Nîmes, France,¹ Laboratoire de Bactériologie, Virologie, Parasitologie, CHU de Nîmes, Groupe Hospitalo-Universitaire de Carémeau, Place du Professeur Robert Debré, 30029 Nîmes Cedex 9, France,² Laboratoire de Bactériologie, CHU Arnaud de Villeneuve, 371, avenue du Doyen Gaston Giraud, 34295 Montpellier cedex 5, France,³ Service de Médecine Interne B, CHU de Nîmes, Groupe Hospitalo-Universitaire de Carémeau, Place du Professeur Robert Debré, 30029 Nîmes Cedex 9, France⁴

Received 14 January 2005/ Returned for modification 28 February 2005/ Accepted 28 March 2005

We report the first strain of glycopeptide-resistant Enterococcus faecium from Europe that contains a vanD allele isolated from blood cultures of an immunocompromised patient hospitalized in a French university hospital. Based on phenotypic results, PCR sequencing, pulsed-field gel electrophoresis, and Southern blotting, the isolate was assigned to E. faecium with a chromosomally located VanD allele most closely related to the VanD1 allele.