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Journal of Clinical Microbiology, July 2005, p. 3530-3532, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3530-3532.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Does Resistance to Pyrazinamide Accurately Indicate the Presence of Mycobacterium bovis?

Bouke C. de Jong,1,2* Anthony Onipede,1,2 Alex S. Pym,1 Sebastien Gagneux,1 Roxanne S. Aga,1 Kathryn DeRiemer,1 and Peter M. Small1,3

Division of Infectious Diseases, Stanford University, Stanford, California,1 MRC Laboratories, Fajara, The Gambia,2 Bill and Melinda Gates Foundation, Seattle, Washington3

Received 11 March 2004/ Accepted 4 April 2005

Mycobacterium bovis is best identified by screening those isolates of the Mycobacterium tuberculosis complex that have any pyrazinamide (PZA) resistance, using a confirmatory test such as spoligotyping, biochemical testing, or genomic deletion analysis. The sensitivity for detection of M. bovis is lowered to 82% when only PZA-monoresistant isolates are screened.

* Corresponding author. Mailing address: MRC Laboratories, Fajara, POB 273, Banjul, The Gambia. Phone: 220-495442. Fax: 220-495919. E-mail: bouke{at}stanford.edu.

Journal of Clinical Microbiology, July 2005, p. 3530-3532, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3530-3532.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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