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Journal of Clinical Microbiology, July 2005, p. 3560-3563, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3560-3563.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Discordant Rise in Galactomannan Antigenemia in a Patient with Resolving Aspergillosis, Renal Failure, and Ongoing Hemodialysis

Chadi M. El Saleeby,1,3 Kim J. Allison,1 Katherine M. Knapp,1,3 Thomas J. Walsh,4 and Randall T. Hayden2*

Departments of Infectious Diseases,1 Pathology, St. Jude Children's Research Hospital,2 Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee,3 Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland4

Received 25 January 2005/ Returned for modification 16 February 2005/ Accepted 22 March 2005

We describe the case of a patient with improving invasive aspergillosis and paradoxically rising serum galactomannan levels in the presence of chronic renal failure and ongoing hemodialysis. Dialysate tested negative for galactomannan, demonstrating the inability of treatments such as hemodialysis to clear Aspergillus antigen from serum. In patients with renal failure and aspergillosis, rising serum galactomannan levels may not necessarily signify progressive infection.

* Corresponding author. Mailing address: Clinical and Molecular Microbiology, Department of Pathology, Mail Stop # 250, St. Jude Children's Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105-2794. Phone: (901) 495-3525. Fax: (901) 495-3100. E-mail: randall.hayden{at}stjude.org.

Journal of Clinical Microbiology, July 2005, p. 3560-3563, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3560-3563.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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