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Journal of Clinical Microbiology, July 2005, p. 3570-3573, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3570-3573.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Involvement of Streptococcal Mitogenic Exotoxin Z in Streptococcal Toxic Shock Syndrome

Lily Yang,1 Mark Thomas,1 Andrew Woodhouse,2 Diana Martin,3 John D. Fraser,1 and Thomas Proft1*

Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand,1 Infectious Disease Unit, Auckland City Hospital, Auckland, New Zealand,2 Institute of Environmental Science and Research Ltd., Porirua, New Zealand3

Received 16 January 2005/ Returned for modification 11 March 2005/ Accepted 16 March 2005

We report a nonfatal case of streptococcal toxic shock syndrome (STSS) caused by a Streptococcus pyogenes emm118 strain encoding a novel variant of streptococcal mitogenic exotoxin Z (SMEZ-34). This variant was responsible for the major mitogenic activity in the cell culture supernatant. Patient sera showed seroconversion toward SMEZ, implying a role for this toxin in STSS.

* Corresponding author. Mailing address: Dept. of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand. Phone: 64-9-373-7599, extension 86213. Fax: 64-9-373-7492. E-mail: t.proft{at}auckland.ac.nz.

Journal of Clinical Microbiology, July 2005, p. 3570-3573, Vol. 43, No. 7
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.7.3570-3573.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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