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Journal of Clinical Microbiology, August 2005, p. 3610-3614, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.3610-3614.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Prevalence of the ST239 Clone of Methicillin-Resistant Staphylococcus aureus and Differences in Antimicrobial Susceptibilities of ST239 and ST5 Clones Identified in a Korean Hospital

Hwa Yun Cha,1 Dong Chan Moon,1 Chul Hee Choi,1 Jae Young Oh,1 Young Sook Jeong,1 Yoo Chul Lee,1,2 Sung Yong Seol,1,2 Dong Taek Cho,1,2 Hyun-Ha Chang,3 Shin-Woo Kim,2,3 and Je Chul Lee1,2*

Department of Microbiology,1 Institute of Infectious Diseases,2 Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea3

Received 1 February 2005/ Returned for modification 11 March 2005/ Accepted 19 April 2005

A total of 188 nonduplicate methicillin-resistant Staphylococcus aureus (MRSA) isolates obtained between 2001 and 2004 in a university hospital in Daegu, Korea, were analyzed for their clonal types by molecular typing techniques, including multilocus sequence typing, spaA typing, staphylococcal chromosomal cassette mec (SCCmec) typing, and pulsed-field gel electrophoresis (PFGE). They were examined for their antimicrobial susceptibilities. The majority (87%) of MRSA isolates belonged to sequence type 239 (ST239; n = 100; 53%) and ST5 (n = 63, 34%) on the basis of sequence typing. MRSA isolates belonging to ST239 were genotypically homogeneous, while those belonging to ST5 showed variations in spaA type, SCCmec type, and PFGE patterns. The rates of resistance of the MRSA isolates belonging to ST239 to trimethoprim, sulfamethoxazole, tobramycin, gentamicin, erythromycin, and tetracycline were significantly higher than those of the isolates belonging to ST5 (P < 0.05). This study demonstrated that the ST239 clone, while rarely detected in Korea, was prevalent and that the antimicrobial susceptibility of the ST239 clone was significantly different from that of the ST5 clone.

* Corresponding author. Mailing address: Department of Microbiology, Kyungpook National University School of Medicine, 101, Dongin-dong, Jung-gu, Daegu, 700-422, Korea. Phone: 82-53-420-4844. Fax: 82-53-427-5664. E-mail: leejc{at}knu.ac.kr.

Journal of Clinical Microbiology, August 2005, p. 3610-3614, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.3610-3614.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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