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Journal of Clinical Microbiology, August 2005, p. 3713-3717, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.3713-3717.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Corynebacterium resistens sp. nov., a New Multidrug-Resistant Coryneform Bacterium Isolated from Human Infections

Yoshihito Otsuka,1,2* Yoshiaki Kawamura,2 Takashi Koyama,2 Hirotoshi Iihara,2 Kiyofumi Ohkusu,2 and Takayuki Ezaki2

Department of Laboratory Medicine, Social Insurance Central General Hospital, Tokyo, Japan,1 Gifu University Graduate School of Medicine, Gifu, Japan2

Received 2 December 2004/ Returned for modification 4 February 2005/ Accepted 17 February 2005

Five strains of an unknown, multidrug-resistant coryneform, gram-positive rod were isolated from blood, bronchial aspirate, and abscess specimens. Four of the five strains isolated were highly resistant to antimicrobial agents, including ß-lactams, aminoglycosides, macrolides, quinolones, and tetracyclines, except for glycopeptides. In immunocompromised patients, bacteremia associated with this organism was rapidly fatal. This coryneform bacterium was nonmotile, lipophilic, and nonsaccharolytic. Lack of pyrazinamidase activity differentiated this organism from other lipophilic corynebacteria. Chemotaxonomic studies indicated that this multidrug-resistant coryneform bacterium belongs to the genus Corynebacterium. Comparative 16S rRNA gene sequencing and DNA-DNA hybridization analyses revealed that the five isolates were genetically identical and that they represent a new subline within the genus Corynebacterium, for which we propose the designation Corynebacterium resistens sp. nov. The type strain of Corynebacterium resistens is GTC 2026T (SICGH 158T, JCM 12819T, CCUG 50093T).

* Corresponding author. Mailing address: Department of Laboratory Medicine, Social Insurance Central General Hospital, Tokyo, Japan. Phone: 81333640251. Fax: 81333640251. E-mail: bac{at}gaea.ocn.ne.jp.

Journal of Clinical Microbiology, August 2005, p. 3713-3717, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.3713-3717.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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