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Journal of Clinical Microbiology, August 2005, p. 4076-4082, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.4076-4082.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Distribution of the Serine Protease Autotransporters of the Enterobacteriaceae among Extraintestinal Clinical Isolates of Escherichia coli

Nick J. Parham, Samantha J. Pollard, Mickaël Desvaux, Anthony Scott-Tucker, Chengjie Liu, Amanda Fivian, and Ian R. Henderson*

Bacterial Pathogenesis and Genomics Unit, Division of Immunity and Infection, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom

Received 21 January 2005/ Returned for modification 9 March 2005/ Accepted 18 April 2005

Urinary tract infections continue to be among the most common extraintestinal diseases. Cystitis in women is by far the most common urinary tract infection; pyelonephritis in both sexes and prostatitis in men are more severe but less frequent complaints. Escherichia coli is by far the most common cause of urinary tract infection. It is believed that uropathogenic E. coli is adept at colonizing the urinary tract via the production of specific virulence factors. Recently, a novel virulence determinant, Vat, was described for the prototypical uropathogenic E. coli strain CFT073. Vat is a member of the SPATE (serine protease autotransporters of the Enterobacteriaceae) subfamily of the autotransporters. Previously, SPATEs have been described for all pathovars of E. coli, but until recently their presence had been noticeably absent in nonpathogenic E. coli. In this report we describe the prevalence and phylogenetic distribution of the SPATEs among uropathogenic E. coli and the ECOR collection, demonstrating an association between the presence of the SPATEs, including Vat, and uropathogenic E. coli phylogroups. In addition, we describe the distribution of SPATEs among nonpathogenic E. coli.

* Corresponding author. Mailing address: Bacterial Pathogenesis and Genomics Unit, Division of Immunity and Infection, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. Phone: 44 (0) 121-414-4368. Fax: 44 (0) 121-414-3599. E-mail: I.R.Henderson{at}bham.ac.uk.

Journal of Clinical Microbiology, August 2005, p. 4076-4082, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.4076-4082.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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