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Journal of Clinical Microbiology, August 2005, p. 4183-4185, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.4183-4185.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Dissemination of CTX-M-Type Extended-Spectrum ß-Lactamase Genes to Unusual Hosts

Dipartimento di Biologia Molecolare, Laboratorio di Fisiologia e Biotecnologia dei Microrganismi, Università di Siena, I-53100 Siena,¹ Laboratorio di Microbiologia Ospedale di Circolo, Università dell'Insubria, I-21100 Varese,² Dipartimento di Scienze e Tecnologie Biomediche, Università di L'Aquila, I-67100 L'Aquila, Italy³

Received 25 January 2005/ Returned for modification 14 February 2005/ Accepted 25 April 2005

A Citrobacter amalonaticus and a Morganella morganii producing the CTX-M-1 extended-spectrum ß-lactamase (ESBL) were isolated from an area where this enzyme is now widespread in Escherichia coli. This is the first report of CTX-M-1 in the former species. In both cases the ESBL determinant was possibly acquired by these unusual hosts in vivo, after coinfection with E. coli strains carrying conjugative plasmids encoding CTX-M-1.

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