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Journal of Clinical Microbiology, August 2005, p. 4191-4193, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.4191-4193.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Partial Excision of the Chromosomal Cassette Containing the Methicillin Resistance Determinant Results in Methicillin-Susceptible Staphylococcus aureus

Pierre-Yves Donnio,1,2* Duarte C. Oliveira,3 Nuno A. Faria,3 Nathalie Wilhelm,4 Alain Le Coustumier,4 and Herminia de Lencastre3,5

Laboratoire de Bactériologie-Virologie, Centre Hospitalier Universitaire, 35033 Rennes, France,1 UPRES-1254 Microbiologie, Université Rennes I, 35043 Rennes, France,2 Instituto de Tecnología Química e Biológica, Universidade Nova de Lisboa, 2780-156 Oeiras, Portugal,3 Laboratoire de Biologie, Centre Hospitalier, 46005 Cahors, France,4 Laboratory of Microbiology, The Rockefeller University, New York, New York 100215

Received 12 March 2005/ Returned for modification 28 April 2005/ Accepted 18 May 2005

We report a detailed characterization of methicillin-susceptible Staphylococcus aureus isolates from five French hospitals negative for both the mecA and the ccrAB loci but positive for the IS431::pUB110::IS431::dcs structure, present in some Staphylococcus cassette chromosome mec (SCCmec) types. The presence of SCCmec-associated elements suggests that this unusual resistant phenotype is due to a partial excision of SCCmec from epidemic methicillin-resistant S. aureus. The hypothesis of a genetic relatedness is strengthened by common sequence and spa types and similar susceptibility patterns.

* Corresponding author. Mailing address: Laboratoire de Bactériologie-Virologie, Centre Hospitalier Universitaire, Rue Henri Le Guilloux, 35033 Rennes, France. Phone: 33-2-99-28-42-76. Fax: 33-2-99-28-41-59. E-mail: pierre-yves.donnio{at}chu-rennes.fr.

Journal of Clinical Microbiology, August 2005, p. 4191-4193, Vol. 43, No. 8
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.8.4191-4193.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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