This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Diggle, M. A. Articles by Clarke, S. C. Search for Related Content PubMed PubMed Citation Articles by Diggle, M. A. Articles by Clarke, S. C.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, September 2005, p. 4649-4653, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4649-4653.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Increased Genetic Diversity of Neisseria meningitidis Isolates after the Introduction of Meningococcal Serogroup C Polysaccharide Conjugate Vaccines

Scottish Meningococcus and Pneumococcus Reference Laboratory, Stobhill Hospital, Glasgow G21 3UW, United Kingdom,¹ Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom²

Received 14 January 2005/ Returned for modification 7 March 2005/ Accepted 4 May 2005

During the 1990s, the incidence of meningococcal disease was high in the United Kingdom. This was due primarily to an increase in serogroup C disease, particularly that within the ET-37/ST-11 genetic lineage. Serogroup C meningococcal polysaccharide conjugate vaccines were introduced in the United Kingdom in 1999, but the sequence types of meningococci causing disease since that time have not yet been reported. We have used serogrouping and multilocus sequence typing to characterize meningococci from patients with invasive disease over a 4-year period and show that there is a significant increase in genetic diversity but no genetic evidence of capsule switching.

This article has been cited by other articles:

• Taha, M.-K., Vazquez, J. A., Hong, E., Bennett, D. E., Bertrand, S., Bukovski, S., Cafferkey, M. T., Carion, F., Christensen, J. J., Diggle, M., Edwards, G., Enriquez, R., Fazio, C., Frosch, M., Heuberger, S., Hoffmann, S., Jolley, K. A., Kadlubowski, M., Kechrid, A., Kesanopoulos, K., Kriz, P., Lambertsen, L., Levenet, I., Musilek, M., Paragi, M., Saguer, A., Skoczynska, A., Stefanelli, P., Thulin, S., Tzanakaki, G., Unemo, M., Vogel, U., Zarantonelli, M. L. (2007). Target Gene Sequencing To Characterize the Penicillin G Susceptibility of Neisseria meningitidis. Antimicrob. Agents Chemother. 51: 2784-2792 [Abstract] [Full Text]  
• Fusco, P. C., Farley, E. K., Huang, C.-H., Moore, S., Michon, F. (2007). Protective Meningococcal Capsular Polysaccharide Epitopes and the Role of O Acetylation. CVI 14: 577-584 [Abstract] [Full Text]  
• Law, D. K. S., Lorange, M., Ringuette, L., Dion, R., Giguere, M., Henderson, A. M., Stoltz, J., Zollinger, W. D., De Wals, P., Tsang, R. S. W. (2006). Invasive Meningococcal Disease in Quebec, Canada, Due to an Emerging Clone of ST-269 Serogroup B Meningococci with Serotype Antigen 17 and Serosubtype Antigen P1.19 (B:17:P1.19).. J. Clin. Microbiol. 44: 2743-2749 [Abstract] [Full Text]