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Journal of Clinical Microbiology, September 2005, p. 4815-4819, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4815-4819.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Coding and Noncoding Genomic Regions of Entamoeba histolytica Have Significantly Different Rates of Sequence Polymorphisms: Implications for Epidemiological Studies

Dhruva Bhattacharya,1 Rashidul Haque,2 and Upinder Singh1,3*

Department of Microbiology and Immunology,1 Department of Internal Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, California 94305-5124,3 Centre for Health and Population Research, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh2

Received 2 June 2005/ Accepted 24 June 2005

To evaluate genetic variability among Entamoeba histolytica strains, we sequenced 9,077 bp from each of 14 isolates. The polymorphism rates from coding and noncoding regions were significantly different (0.07% and 0.37%, respectively), indicating that these regions are subject to different selection pressures. Additionally, single nucleotide polymorphisms (SNPs) potentially associated with specific clinical outcomes were identified.

* Corresponding author. Mailing address: Department of Medicine, Division of Infectious Diseases, S-143 Grant Building, 300 Pasteur Drive, Stanford, CA 94305. Phone: (650) 723-4045. Fax: (650) 724-3892. E-mail: usingh{at}stanford.edu.

Journal of Clinical Microbiology, September 2005, p. 4815-4819, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4815-4819.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • MacFarlane, R. C., Singh, U. (2006). Identification of Differentially Expressed Genes in Virulent and Nonvirulent Entamoeba Species: Potential Implications for Amebic Pathogenesis. Infect. Immun. 74: 340-351 [Abstract] [Full Text]  


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