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Journal of Clinical Microbiology, September 2005, p. 4862-4864, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4862-4864.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Widespread Transfer of Resistance Genes between Bacterial Species in an Intensive Care Unit: Implications for Hospital Epidemiology

Nashwan Al Naiemi,1 Birgitta Duim,1* Paul H. M. Savelkoul,3 Lodewijk Spanjaard,1 Evert de Jonge,2 Aldert Bart,1 Christina M. Vandenbroucke-Grauls,1,3 and Menno D. de Jong1,{dagger}

Academic Medical Center, Departments of Medical Microbiology,1 Intensive Care, Amsterdam, The Netherlands,2 VU University Medical Center, Medical Microbiology and Infection Control, Amsterdam, The Netherlands3

Received 15 June 2005/ Accepted 23 June 2005

A transferable plasmid encoding SHV-12 extended-spectrum ß-lactamase, TEM-116, and aminoglycoside resistance was responsible for two sequential clonal outbreaks of Enterobacter cloacae and Acinetobacter baumannii bacteria. A similar plasmid was present among isolates of four different bacterial species. Recognition of plasmid transfer is crucial for control of outbreaks of multidrug-resistant nosocomial pathogens.

* Corresponding author. Mailing address: Academic Medical Center, Dept. of Medical Microbiology, L1-244, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Phone: 31 20 5665714. Fax: 31 20 5669745. E-mail: b.duim{at}amc.uva.nl.

{dagger} Present address: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.

Journal of Clinical Microbiology, September 2005, p. 4862-4864, Vol. 43, No. 9
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.9.4862-4864.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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