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Journal of Clinical Microbiology, January 2006, p. 183-191, Vol. 44, No. 1
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.1.183-191.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Long-Term Population-Based Genotyping Study of Mycobacterium tuberculosis Complex Isolates in the French Departments of the Americas{dagger}

Karine Brudey,1 Ingrid Filliol,1 Séverine Ferdinand,1 Vanina Guernier,2 Philippe Duval,3 Bertrand Maubert,3 Christophe Sola,1* and Nalin Rastogi1*

Unité de la tuberculose et des Mycobactéries, Institut Pasteur de Guadeloupe, F97183 Abymes Cedex, Guadeloupe,1 Institut de Recherche pour le Développement, F97323,2 Institut Pasteur de Cayenne, F97306, Cayenne Cedex, French Guiana3

Received 19 May 2005/ Returned for modification 13 July 2005/ Accepted 26 October 2005

The three French overseas departments of the Americas are characterized both by insular (Guadeloupe and Martinique) and continental (French Guiana) settings with a tuberculosis case detection rate that varies from less than 10 per 100,000 per year in insular areas to an estimated incidence of more than 55 per 100,000 in French Guiana. Under a long-term genotyping program, more than three-fourths of all the Mycobacterium tuberculosis isolates (n = 744) received from the three settings were fingerprinted over a 10-year period (1994 to 2003) by spoligotyping and variable number of tandem DNA repeats (VNTRs) in order to understand the current trends in their detection rates, drug resistance, and groups and subpopulations at risk of contracting the disease and to pinpoint the circulating phylogeographical clades of the bacilli. The major difference in the study populations was the nationality of the patients, with a high percentage of immigrants from high-incidence neighboring countries in French Guiana and a low but increasing percentage in the French Caribbean. The rate of recent transmission was calculated to be 49.3% in French Guiana, compared to 27.2% and 16.9% in Guadeloupe and Martinique, respectively. At the phylogeographic level, 77.9% of the isolates studied belonged to four major clades (Haarlem, Latin-American and Mediterranean, T, and X) which are already reported from neighboring Caribbean islands in an international database and may underline potential interregional transmission events.

* Corresponding author. Mailing address: Institut Pasteur de Guadeloupe, Morne Jolivière, BP484, F97183 Abymes, Guadeloupe. Phone: 590-590-893881. Fax: 590-590-893880. E-mail address for N. Rastogi: nrastogi{at}pasteur-guadeloupe.fr. E-mail address for C. Sola: csola{at}pasteur-guadeloupe.fr.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org/.

Journal of Clinical Microbiology, January 2006, p. 183-191, Vol. 44, No. 1
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.1.183-191.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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