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Journal of Clinical Microbiology, January 2006, p. 229-231, Vol. 44, No. 1
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.1.229-231.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Does Nasal Cocolonization by Methicillin-Resistant Coagulase-Negative Staphylococci and Methicillin-Susceptible Staphylococcus aureus Strains Occur Frequently Enough To Represent a Risk of False-Positive Methicillin-Resistant S. aureus Determinations by Molecular Methods?

Institute of Medical Microbiology,¹ Department of Thoracic and Cardiovascular Surgery,² Institute for Hygiene, University Hospital of Münster, 48149 Münster, Germany³

Received 12 October 2005/ Accepted 17 October 2005

By analyzing the colonization of the anterior nares in cardiothoracic surgery patients on admission, nasal cocolonization by methicillin-susceptible Staphylococcus aureus and methicillin-resistant coagulase-negative staphylococci was detected in 8/235 (3.4%) specimens. Consequently, in a low-methicillin-resistant S. aureus (MRSA) setting, a molecular MRSA screening test targeting the mecA gene and an S. aureus-specific gene in parallel and applied directly to clinical specimens would be associated with an unacceptable positive predictive value of about 40%.

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