This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sundar, S.
Right arrow Articles by Murray, H. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sundar, S.
Right arrow Articles by Murray, H. W.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, January 2006, p. 251-253, Vol. 44, No. 1
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.1.251-253.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Rapid, Noninvasive Diagnosis of Visceral Leishmaniasis in India: Comparison of Two Immunochromatographic Strip Tests for Detection of Anti-K39 Antibody

Shyam Sundar,1* Radheshyam Maurya,1 Rakesh K. Singh,1 K. Bharti,1 Jaya Chakravarty,1 Ashish Parekh,1 Madhukar Rai,1 Kailash Kumar,1 and Henry W. Murray2

Kala-Azar Medical Research Center, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India,1 Department of Medicine, Weill Medical College of Cornell University, New York, New York 100212

Received 20 July 2005/ Returned for modification 6 September 2005/ Accepted 21 October 2005

Used with blood or serum, a new anti-K39 antibody immunochromatographic strip test (IT-Leish; DiaMed AG) proved sensitive (range, 99 to 100%) and specific (range, 95 to 100%) for the noninvasive serodiagnosis of visceral leishmaniasis in India. Used with serum, the IT-Leish test and the existing Kalazar Detect test (InBios International, Inc.) yielded comparable results for symptomatic infection and identified apparent subclinical infection in 15 to 32% of healthy residents in a region where visceral leishmaniasis is highly endemic.

* Corresponding author. Mailing address: Kala-Azar Medical Research Center, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, 6 SK Gupta Nagar, Lanka, Varanasi 221005, India. Phone: 91-542-2367795. Fax: 91-542-2367568. E-mail: shyam_vns{at}sify.com.

Journal of Clinical Microbiology, January 2006, p. 251-253, Vol. 44, No. 1
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.1.251-253.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • ter Horst, R., Tefera, T., Assefa, G., Ebrahim, A. Z., Davidson, R. N., Ritmeijer, K. (2009). Field Evaluation of rK39 Test and Direct Agglutination Test for Diagnosis of Visceral Leishmaniasis in a Population with High Prevalence of Human Immunodeficiency Virus in Ethiopia. Am J Trop Med Hyg 80: 929-934 [Abstract] [Full Text]  
  • Roddy, P., Goiri, J., Flevaud, L., Palma, P. P., Morote, S., Lima, N., Villa, L., Torrico, F., Albajar-Vinas, P. (2008). Field Evaluation of a Rapid Immunochromatographic Assay for Detection of Trypanosoma cruzi Infection by Use of Whole Blood. J. Clin. Microbiol. 46: 2022-2027 [Abstract] [Full Text]  
  • Myles, O., Wortmann, G. W., Cummings, J. F., Barthel, R. V., Patel, S., Crum-Cianflone, N. F., Negin, N. S., Weina, P. J., Ockenhouse, C. F., Joyce, D. J., Magill, A. J., Aronson, N. E., Gasser, R. A. Jr (2007). Visceral Leishmaniasis: Clinical Observations in 4 US Army Soldiers Deployed to Afghanistan or Iraq, 2002-2004. Arch Intern Med 167: 1899-1901 [Full Text]  
  • Alvar, J., Bashaye, S., Argaw, D., Cruz, I., Aparicio, P., Kassa, A., Orfanos, G., Parreno, F., Babaniyi, O., Gudeta, N., Canavate, C., Bern, C. (2007). Kala-Azar Outbreak in Libo Kemkem, Ethiopia: Epidemiologic and Parasitologic Assessment. Am J Trop Med Hyg 77: 275-282 [Abstract] [Full Text]  
  • Sundar, S., Jha, T.K., Thakur, C. P., Sinha, P. K., Bhattacharya, S. K. (2007). Injectable Paromomycin for Visceral Leishmaniasis in India. NEJM 356: 2571-2581 [Abstract] [Full Text]  
  • Goto, Y., Coler, R. N., Reed, S. G. (2007). Bioinformatic Identification of Tandem Repeat Antigens of the Leishmania donovani Complex. Infect. Immun. 75: 846-851 [Abstract] [Full Text]  
  • Lockwood, D. N J, Sundar, S. (2006). Serological tests for visceral leishmaniasis.. BMJ 333: 711-712 [Full Text]  
  • Chappuis, F., Rijal, S., Soto, A., Menten, J., Boelaert, M. (2006). A meta-analysis of the diagnostic performance of the direct agglutination test and rK39 dipstick for visceral leishmaniasis. BMJ 333: 723- [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»