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Journal of Clinical Microbiology, January 2006, p. 47-50, Vol. 44, No. 1
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.1.47-50.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Positive Correlation between Epstein-Barr Virus Viral Load and Anti-Viral Capsid Immunoglobulin G Titers Determined for Hodgkin's Lymphoma Patients and Their Relatives

Caroline Besson,1,2 Corinne Amiel,3 Catherine Le-Pendeven,3 Pauline Brice,4 Christophe Fermé,5 Patrice Carde,5 Olivier Hermine,6 Martine Raphael,2 Laurent Abel,1* and Jean-Claude Nicolas3

Laboratoire de Génétique Humaine des Maladies Infectieuses, Faculté Necker, Université de Paris René Descartes INSERM U550, Paris, France,1 Service d'Hématologie, Immunologie biologiques, Hôpital Bicêtre, Le Kremlin-Bicêtre, France,2 Laboratoire de Virologie, Hôpital Tenon, Paris, France,3 Service d'Onco-hématologie, Hôpital Saint-Louis, Paris, France,4 Département d'Hématologie, Institut Gustave Roussy, Paris, France,5 Service d'Hématologie adultes, Hôpital Necker, Paris, France6

Received 7 July 2005/ Returned for modification 22 September 2005/ Accepted 8 October 2005

Markers of Epstein-Barr virus (EBV) infection include measures of specific serological titers and of viral load (VLo) in peripheral blood mononuclear cells. Few studies have investigated the correlation between these two phenotypes. Here, we found that there was no correlation between VLo and either anti-EBV nuclear antigen type 1 or anti-early antigen immunoglobulin G (IgG) titer but that anti-viral capsid antigen (VCA) IgG titer increased with VLo in peripheral blood mononuclear cells in patients with Hodgkin's lymphoma (P = 3.10–3). A similar pattern was observed in healthy first-degree relatives (parents and siblings) of patients (P = 6.10–4). Our results indicate that anti-VCA IgG titers and EBV VLo are specifically correlated EBV phenotypes.

* Corresponding author. Mailing address: Laboratoire de Génétique Humaine des Maladies Infectieuses, Faculté Necker, Université de Paris René Descartes INSERM U550, 75015 Paris, France. Phone: 33 1 40 61 56 89. Fax: 33 1 40 61 56 88. mail: E-mail: abel{at}necker.fr.

Journal of Clinical Microbiology, January 2006, p. 47-50, Vol. 44, No. 1
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.1.47-50.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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