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Journal of Clinical Microbiology, October 2006, p. 3781-3783, Vol. 44, No. 10
0095-1137/06/$08.00+0     doi:10.1128/JCM.01249-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Age Dependence of Adenovirus-Specific Neutralizing Antibody Titers in Individuals from Sub-Saharan Africa

Anna R. Thorner,1 Ronald Vogels,2 Jorn Kaspers,2 Gerrit J. Weverling,2 Lennart Holterman,2 Angelique A. C. Lemckert,2 Athmanundh Dilraj,3 Lisa M. McNally,4 Prakash M. Jeena,4 Soren Jepsen,5 Peter Abbink,1 Anjali Nanda,1 Patricia E. Swanson,1 Andrew T. Bates,1 Kara L. O'Brien,1 Menzo J. E. Havenga,2 Jaap Goudsmit,2 and Dan H. Barouch1*

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts,1 Crucell Holland BV, Leiden, The Netherlands,2 South African Medical Research Council, Durban, South Africa,3 University of KwaZulu-Natal, Durban, South Africa,4 European Malaria Vaccine Initiative, Copenhagen, Denmark5

Received 18 June 2006/ Returned for modification 22 June 2006/ Accepted 24 July 2006

We assessed neutralizing antibody titers to adenovirus serotype 5 (Ad5) and six rare adenovirus serotypes, serotypes 11, 35, 50, 26, 48, and 49, in pediatric populations in sub-Saharan Africa. We observed a clear age dependence of Ad5-specific neutralizing antibody titers. These data will help to guide the development of Ad vector-based vaccines for human immunodeficiency virus type 1 and other pathogens.

* Corresponding author. Mailing address: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Research East, Room 213, 330 Brookline Avenue, Boston, MA 02215. Phone: (617) 667-4434. Fax: (617) 667-8210. E-mail: dbarouch{at}bidmc.harvard.edu.

Journal of Clinical Microbiology, October 2006, p. 3781-3783, Vol. 44, No. 10
0095-1137/06/$08.00+0     doi:10.1128/JCM.01249-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2006 by the American Society for Microbiology. All rights reserved.