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Journal of Clinical Microbiology, October 2006, p. 3814-3818, Vol. 44, No. 10
0095-1137/06/$08.00+0     doi:10.1128/JCM.00881-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Daptomycin, Ciprofloxacin, and Other Antimicrobial Agents against the Cells and Spores of Clinical Isolates of Bacillus Species

Diane M. Citron1* and Maria D. Appleman2

Los Angeles County/University of Southern California Medical Center,1 USC Keck School of Medicine, Los Angeles, California2

Received 26 April 2006/ Returned for modification 22 June 2006/ Accepted 3 August 2006

Daptomycin inhibited 67 of 70 clinical isolates of Bacillus species at ≤1 µg/ml and 100% of them at ≤2 µg/ml. It showed bactericidal activity similar to that of ciprofloxacin against vegetative cells but not against spores. For 2 strains, the ciprofloxacin MICs were >4 g/ml, and 10 strains were resistant to erythromycin.

* Corresponding author. Mailing address: Microbial Research Lab, 2G-24, LAC+USC Medical Center, 1801 Marengo Street, Los Angeles, CA 90033. Phone: (323) 226-3749. Fax: (323) 226-7021. E-mail: dcitron{at}usc.edu.

Journal of Clinical Microbiology, October 2006, p. 3814-3818, Vol. 44, No. 10
0095-1137/06/$08.00+0     doi:10.1128/JCM.00881-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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