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Journal of Clinical Microbiology, October 2006, p. 3819-3821, Vol. 44, No. 10
0095-1137/06/$08.00+0     doi:10.1128/JCM.02495-05
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Distribution of hsp65 PCR-Restriction Enzyme Analysis Patterns among Mycobacterium avium Complex Isolates in Thailand

National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Thailand Science Park, Pathumthani, Thailand 12120,¹ Department of Applied Biology, Faculty of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand 10520,² Molecular Mycology and Mycobacteriology Laboratory, Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand 10700,³ Host Defense Unit, Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 10400⁴

Received 1 December 2006/ Returned for modification 13 February 2006/ Accepted 13 August 2006

A total of 227 clinical Mycobacterium avium complex isolates from Thailand were differentiated into species and types by using PCR-restriction enzyme analysis of hsp65. The distribution of types showed the predominance of M. avium I (77%) in blood specimens, whereas M. intracellulare I was more commonly found in pulmonary specimens (44.2%). In addition, infections with M. avium were more likely to be found in younger adults (20 to 39 years old), while infections with M. intracellulare were more likely to be found in older adults (60 years old). Our results provide the useful epidemiological information that some particular types have more invasive and virulent characters than others.

Published ahead of print on 23 August 2006.

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