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Journal of Clinical Microbiology, October 2006, p. 3830-3832, Vol. 44, No. 10
0095-1137/06/$08.00+0     doi:10.1128/JCM.01062-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Treatment Failure of Nosocomial Pertussis Infection in a Very-Low-Birth-Weight Neonate

Stéphane Bonacorsi,1 Caroline Farnoux,2 Philippe Bidet,1 Valérie Caro,4 Sophie Aizenfisz,3 Mounir Benhayoun,3 Yannick Aujard,2 Nicole Guiso,4 and Edouard Bingen1*

Laboratoire d'Etudes de Génétique Bactérienne dans les Infections de l'Enfant (EA 3105), Université Denis Diderot-Paris 7, Service de Microbiologie,1 Service de Néonatologie,2 Service de Réanimation, Hôpital Robert Debré (AP-HP), 75019 Paris, France,3 Centre National de Référence de la Coqueluche et autres Bordetelloses, Institut Pasteur, 75015 Paris, France4

Received 22 May 2006/ Returned for modification 1 July 2006/ Accepted 22 July 2006

We describe a case of nosocomial maternal transmission of Bordetella pertussis to a very-low-birth-weight (VLBW) neonate in whom treatment was unsuccessful. This case underscores the need for rapid and sensitive PCR diagnosis in VLBW neonates and in parents with clinical signs of pertussis and suggests that standard treatment may not be appropriate for VLBW neonates.

* Corresponding author. Mailing address: Service de Microbiologie, Hôpital Robert-Debré, 48 boulevard Sérurier, 75395 Paris cedex 19, France. Phone: 33 1 40 03 23 40. Fax: 33 1 40 03 24 50. E-mail: edouard.bingen{at}rdb.aphp.fr.

Journal of Clinical Microbiology, October 2006, p. 3830-3832, Vol. 44, No. 10
0095-1137/06/$08.00+0     doi:10.1128/JCM.01062-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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