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Pilot Study of a Commercialized Human Papillomavirus (HPV) Genotyping Assay: Comparison of HPV Risk Group to Cytology and Histology

Division of Cancer Epidemiology, National Cancer Institute, NIH, DHHS, Bethesda, Maryland,¹ Roche Molecular Systems, Alameda, California,² University of Arizona Health Sciences Center, Tucson, Arizona,³ Medical University of South Carolina, Charleston, South Carolina⁴

Received 26 June 2006/ Returned for modification 8 August 2006/ Accepted 30 August 2006

We evaluated a commercialized PCR assay, Linear Array, that detects 37 human papillomavirus (HPV) genotypes, using a sample of liquid cytology specimens (n = 534). We found a strong association of an increasing level of HPV risk (HPV type 16 [HPV16] > HPV18 > other carcinogenic types > noncarcinogenic types > negative specimens) with increasing severities of cytologic interpretations (P_Trend < 0.0005) and histologic diagnoses (P_Trend < 0.0005).

Published ahead of print on 13 September 2006.

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