This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Caws, M.
Right arrow Articles by Farrar, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Caws, M.
Right arrow Articles by Farrar, J.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, November 2006, p. 3934-3939, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.01181-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Beijing Genotype of Mycobacterium tuberculosis Is Significantly Associated with Human Immunodeficiency Virus Infection and Multidrug Resistance in Cases of Tuberculous Meningitis{triangledown}

Maxine Caws,1,5* Guy Thwaites,2 Kasia Stepniewska,4,5 Nguyen Thi Ngoc Lan,3 Nguyen Thi Hong Duyen,1 Nguyen Thi Phuong,1 Mai Nguyet Thu Huyen,3 Phan Minh Duy,1 Tran Huu Loc,3 Tran Thi Hong Chau,6 Dick van Soolingen,7 Kristin Kremer,7 Nguyen Van Vinh Chau,4 Nguyen Tran Chinh,6 and Jeremy Farrar1,5

Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam,1 Brighton and Sussex University Hospital, Department of Infectious Diseases and Microbiology, Eastern Road, Brighton, Sussex, BN2 5BE, United Kingdom,2 Pham Ngoc Thach Hospital for Tuberculosis and Lung Diseases, Huong Vuong, District 5, Ho Chi Minh City, Vietnam,3 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand,4 Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom,5 The Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam,6 Tuberculosis Reference Laboratory, National Institute for Public Health, Antonie van Leeuwenhoeklaan 9, Bilthoeven, 3721 BA, The Netherlands7

Received 8 June 2006/ Returned for modification 12 July 2006/ Accepted 16 August 2006

Multidrug-resistant tuberculous meningitis is fatal without rapid diagnosis and use of second-line therapy. It is more common in human immunodeficiency virus (HIV)-positive patients. Beijing genotype strains of Mycobacterium tuberculosis are associated with drug resistance, particularly multidrug resistance, and their prevalence is increasing worldwide. The prevalence of Beijing genotype strains among Mycobacterium tuberculosis isolates from the cerebrospinal fluid of HIV-positive (n = 35) and HIV-negative (n = 187) patients in Ho Chi Minh City was determined. The Beijing genotype was significantly associated with HIV status (odds ratio [OR] = 2.95 [95% confidence interval {CI}, 1.38 to 6.44]; P = 0.016), resistance to any drug (OR = 3.34 [95% CI, 1.87 to 5.95]; P < 0.001) and multidrug resistance (Fisher's exact test; P = 0.001). The association of the Beijing genotype with drug resistance was independent of HIV status. This is the first report of Beijing genotype association with HIV status, which may be an association unique to tuberculous meningitis.

* Corresponding author. Mailing address: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam. Phone: (84 8) 8384013. Fax: (84 8) 8353904. E-mail: mcaws{at}hotmail.com.

{triangledown} Published ahead of print on 13 September 2006.

Journal of Clinical Microbiology, November 2006, p. 3934-3939, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.01181-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • An, D. D., Hong Duyen, N. T., Lan, N. T. N., Hoa, D. V., Ha, D. T. M., Kiet, V. S., Thu, D. D. A., Van Vinh Chau, N., Dung, N. H., Sy, D. N., Farrar, J., Caws, M. (2009). Beijing Genotype of Mycobacterium tuberculosis Is Significantly Associated with High-Level Fluoroquinolone Resistance in Vietnam. Antimicrob. Agents Chemother. 53: 4835-4839 [Abstract] [Full Text]  
  • Reed, M. B., Pichler, V. K., McIntosh, F., Mattia, A., Fallow, A., Masala, S., Domenech, P., Zwerling, A., Thibert, L., Menzies, D., Schwartzman, K., Behr, M. A. (2009). Major Mycobacterium tuberculosis Lineages Associate with Patient Country of Origin. J. Clin. Microbiol. 47: 1119-1128 [Abstract] [Full Text]  
  • Feng, J.-Y., Su, W.-J., Tsai, C.-C., Chang, S.-C. (2008). Clinical Impact of Mycobacterium tuberculosis W-Beijing Genotype Strain Infection on Aged Patients in Taiwan. J. Clin. Microbiol. 46: 3127-3129 [Abstract] [Full Text]  
  • Rock, R. B., Olin, M., Baker, C. A., Molitor, T. W., Peterson, P. K. (2008). Central Nervous System Tuberculosis: Pathogenesis and Clinical Aspects. Clin. Microbiol. Rev. 21: 243-261 [Abstract] [Full Text]  
  • Thwaites, G., Caws, M., Chau, T. T. H., D'Sa, A., Lan, N. T. N., Huyen, M. N. T., Gagneux, S., Anh, P. T. H., Tho, D. Q., Torok, E., Nhu, N. T. Q., Duyen, N. T. H., Duy, P. M., Richenberg, J., Simmons, C., Hien, T. T., Farrar, J. (2008). Relationship between Mycobacterium tuberculosis Genotype and the Clinical Phenotype of Pulmonary and Meningeal Tuberculosis. J. Clin. Microbiol. 46: 1363-1368 [Abstract] [Full Text]  
  • Lazzarini, L. C. O., Huard, R. C., Boechat, N. L., Gomes, H. M., Oelemann, M. C., Kurepina, N., Shashkina, E., Mello, F. C. Q., Gibson, A. L., Virginio, M. J., Marsico, A. G., Butler, W. R., Kreiswirth, B. N., Suffys, P. N., Lapa e Silva, J. R., Ho, J. L. (2007). Discovery of a Novel Mycobacterium tuberculosis Lineage That Is a Major Cause of Tuberculosis in Rio de Janeiro, Brazil. J. Clin. Microbiol. 45: 3891-3902 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»