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Journal of Clinical Microbiology, November 2006, p. 4142-4148, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.01049-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

FDJS03 Isolates Causing an Outbreak of Aseptic Meningitis in China That Evolved from a Distinct Echovirus 30 Lineage Imported from Countries of the Commonwealth of Independent States{triangledown}

Ya Nan Zhao,1,{dagger} David S. Perlin,2,{dagger} Steven Park,2 Ren Jie Jiang,3 Liang Chen,1 Yue Chen,4 Rebecca Gardiner,2 and Qing Wu Jiang1*

School of Public Health, Fudan University, Shanghai, China,1 Public Health Research Institute, Newark, New Jersey,2 Yancheng Center for Disease Prevention & Control, Yancheng, Jiangsu, China,3 University of Ottawa, Ottawa, Canada,4 4

Received 19 May 2006/ Returned for modification 3 August 2006/ Accepted 30 August 2006

We compared echovirus 30 strains (FDJS03) which caused an outbreak of aseptic meningitis in China in 2003 with other human enterovirus B strains. Sequencing of the complete genome of FDJS03_84, a representative strain from this outbreak, revealed a mosaic structure with a putative recombination spot within the 2B gene. It was most similar to a strain of the same serotype, E30-14125-00, in the 5' half of the genome but was almost equidistant to all strains analyzed in most of the 3' half of the genome. Phylogenetic relationships in the 5'-untranslated region and the VP1 gene indicated that the FDJS03 isolates were closely related to a distinct lineage of E30 which circulated in countries of the Commonwealth of Independent States during 1999 and 2000. It is most likely that the ancestor of FDJS03 isolates experienced multiple recombination events in the nonstructural protein coding region, which were partly observed in the phylogenetic analysis of the 3D region.

* Corresponding author. Mailing address: Department of Epidemiology, School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China. Phone: 86-21-54237435. Fax: 86-21-64037350. E-mail: epicorrespond{at}yahoo.com.cn.

{triangledown} Published ahead of print on 6 September 2006.

{dagger} Ya Nan Zhao and David S. Perlin contributed equally to this paper.

Journal of Clinical Microbiology, November 2006, p. 4142-4148, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.01049-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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