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Journal of Clinical Microbiology, November 2006, p. 4189-4192, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.00796-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Outbreak of Infection by Carbapenem-Resistant Acinetobacter baumannii Producing the Carbapenemase OXA-58 in Belgium{triangledown}

Pierre Bogaerts,1* Thierry Naas,2 Ingrid Wybo,3 Caroline Bauraing,1 Oriane Soetens,3 Denis Piérard,3 Patrice Nordmann,2 and Youri Glupczynski1

Laboratoire de Bactériologie, Cliniques Universitaires UCL de Mont-Godinne, B-5530 Yvoir, Belgium,1 Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, Le Kremlin-Bicêtre, France,2 Dienst Microbiologie en Ziekenhuishygiëne, Academisch Ziekenhuis Vrije Universiteit Brussel, B-1090 Brussels, Belgium3

Received 13 April 2006/ Returned for modification 8 August 2006/ Accepted 25 August 2006

Carbapenem-resistant Acinetobacter baumannii isolates were obtained from 17 patients between September 2004 and August 2005 at the Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium. These multidrug-resistant isolates, which belonged to a single clone, remained susceptible to colistin and tigecycline only and produced the carbapenem-hydrolyzing oxacillinase OXA-58. This study highlights the importance of the intercountry spread of this ß-lactamase-mediated resistance mechanism and its epidemic evolution.

* Corresponding author. Mailing address: Laboratoire de Bactériologie, Cliniques Universitaires UCL de Mont-Godinne, 1, Av. Dr Gaston Thérasse, B-5530 Yvoir, Belgium. Phone: 32-81-42-32-41. Fax: 32-81-42-32-46. E-mail: pierre.bogaerts{at}mont.ucl.ac.be.

{triangledown} Published ahead of print on 6 September 2006.

Journal of Clinical Microbiology, November 2006, p. 4189-4192, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.00796-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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