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Journal of Clinical Microbiology, November 2006, p. 4208-4210, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.00902-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

In Vitro Antifungal-Drug Susceptibilities of Mycelial and Yeast Forms of Penicillium marneffei Isolates in Cambodia{triangledown}

Borann Sar,1* Sambo Boy,1 Chantary Keo,1 Chan Chhaya Ngeth,2 Narom Prak,2 Mich Vann,2 Didier Monchy,1 and Jean Louis Sarthou1

Laboratory of Medical Microbiology, Unit of Clinical Testing, Institut Pasteur du Cambodge, 5 Boulevard Monivong, BP 983, Phnom Penh, Cambodia,1 Department of Infectious Diseases, Preah Bat Norodom Sihanouk Hospital, Phnom Penh, Cambodia2

Received 1 May 2006/ Returned for modification 19 June 2006/ Accepted 14 August 2006

Penicillium marneffei infection is an important disease among human immunodeficiency virus patients in Southeast Asia. The in vitro antifungal-drug susceptibilities of 29 clinical isolates and 5 isolates from bamboo rats collected from 2002 to 2004 were determined. The P. marneffei yeast form is more susceptible than the mycelial form to amphotericin B and ketoconazole, while the mycelial and yeast forms displayed similar susceptibilities to flucytosine and itraconazole. The MICs of fluconazole were higher for both mycelial and yeast forms.

* Corresponding author. Mailing address: Laboratory of Medical Microbiology, Unit of Clinical Testing, Institut Pasteur du Cambodge, 5 Boulevard Monivong, BP 983, Phnom Penh, Cambodia. Phone: 855-23-368-036. Fax: 855-23-426-013. E-mail: sborann{at}pasteur-kh.org.

{triangledown} Published ahead of print on 13 September 2006.

Journal of Clinical Microbiology, November 2006, p. 4208-4210, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.00902-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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