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Journal of Clinical Microbiology, November 2006, p. 4222-4226, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.01376-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Presence of Copper- and Zinc-Containing Superoxide Dismutase in Commensal Haemophilus haemolyticus Isolates Can Be Used as a Marker To Discriminate Them from Nontypeable H. influenzae Isolates

W. W. Mary Fung,^1, Clíona A. O'Dwyer,^1, Sunita Sinha,¹ Aimee L. Brauer,² Timothy F. Murphy,² J. Simon Kroll,¹ and Paul R. Langford^1*

Department of Paediatrics, Division of Medicine, Imperial College, St. Mary's Campus, London W2 1PG, United Kingdom,¹ Departments of Microbiology and Medicine, University of Buffalo, State University of New York, and VA Western New York Healthcare System, Buffalo, New York²

Received 5 July 2006/ Returned for modification 30 August 2006/ Accepted 3 September 2006

Respiratory isolates of Haemophilus haemolyticus are regularly misclassified as nontypeable (NT) Haemophilus influenzae due to an aberrant hemolytic reaction on blood agar, with implications for treatment. The presence of sodC or its cognate protein, copper-zinc superoxide dismutase, can distinguish respiratory isolates of H. haemolyticus from NT H. influenzae with 100% accuracy.

Published ahead of print on 20 September 2006.

W.W.M.F. and C.A.O. contributed equally to the work.

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