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Journal of Clinical Microbiology, November 2006, p. 4273-4275, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.00970-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

CASE REPORT

What Does Detection of Mycobacterium ulcerans DNA in the Margin of an Excised Buruli Ulcer Lesion Tell Us?{triangledown}

Simona Rondini,1* Ernestina Mensah-Quainoo,2 Thomas Junghanss,3 and Gerd Pluschke1

Molecular Immunology, Swiss Tropical Institute, Basel, Switzerland,1 Ghana Health Service, Ga West District, Ghana,2 Section of Clinical Tropical Medicine, University Hospital Heidelberg, Heidelberg, Germany3

Received 9 May 2006/ Returned for modification 3 July 2006/ Accepted 15 August 2006

We determined by real-time PCR the distribution of Mycobacterium ulcerans DNA in the excised lesion of a Buruli ulcer patient. A new lesion developed adjacent to the site of excision in the patient. The excised margin around the primary lesion contained a small amount of mycobacterial DNA in the area where the secondary lesion developed. These results suggest that a relatively small number of infiltrating mycobacteria can lead to the development of a recurrence.

* Corresponding author. Present address: Division of Infectious Diseases and International Health, Department of Medicine, Weill Medical College of Cornell University 1300 York Avenue, New York, NY 10021. Phone: (212) 746-6324. Fax: (212) 746-8675. E-mail: sir2004{at}med.cornell.edu.

{triangledown} Published ahead of print on 23 August 2006.

Journal of Clinical Microbiology, November 2006, p. 4273-4275, Vol. 44, No. 11
0095-1137/06/$08.00+0     doi:10.1128/JCM.00970-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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