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Journal of Clinical Microbiology, December 2006, p. 4342-4344, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.01550-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Determination of MICs of Aminocandin for Candida spp. and Filamentous Fungi{triangledown}

N. Isham and M. A. Ghannoum*

Center for Medical Mycology, University Hospitals of Cleveland/Case Western Reserve University, Cleveland, Ohio

Received 26 July 2006/ Returned for modification 14 September 2006/ Accepted 25 September 2006

Candida and Aspergillus spp., as well as other filamentous molds, have increasingly been reported as the causes of severe invasive fungal infections. We evaluated the new echinocandin aminocandin (AMN) for its antifungal activities against a range of fungal pathogens by determination of the MICs for the organisms. The MICs of the comparator drugs amphotericin B, caspofungin, micafungin, and voriconazole were also determined. The MICs of AMN for 25 strains each of non-Candida albicans Candida spp. (including Candida parapsilosis, Candida krusei, Candida guilliermondii, and Candida tropicalis), Aspergillus fumigatus, Scedosporium spp., Fusarium spp., and zygomycetes (including Absidia, Mucor, and Rhizopus spp.) were determined by using the Clinical and Laboratory Standards Institute M27-A2 and M38-A methodologies for yeasts and filamentous molds, respectively. The MIC ranges of AMN for all yeasts were similar (0.03 to 4.0 µg/ml), while the MIC ranges of AMN for filamentous fungi were species specific. AMN demonstrated potent antifungal activity against A. fumigatus, limited activity against Scedosporium spp., and no activity against zygomycetes or Fusarium spp. Our data showed that AMN demonstrated potent antifungal activities against all of the yeasts and Aspergillus isolates tested, suggesting that AMN could be an important addition to our arsenal of antifungals for the treatment of invasive fungal disease.

* Corresponding author. Mailing address: Center for Medical Mycology, University Hospitals of Cleveland/Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106. Phone: (216) 844-8580. Fax: (216) 844-1076. E-mail: mahmoud.ghannoum{at}uhhs.com.

{triangledown} Published ahead of print on 4 October 2006.

Journal of Clinical Microbiology, December 2006, p. 4342-4344, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.01550-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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