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Journal of Clinical Microbiology, December 2006, p. 4547-4549, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.01611-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Assessing the Genetic Diversity of the Aldolase Genes of Plasmodium falciparum and Plasmodium vivax and Its Potential Effect on Performance of Aldolase-Detecting Rapid Diagnostic Tests{triangledown}

Nelson Lee,1,2 Joanne Baker,2 David Bell,3 James McCarthy,1 and Qin Cheng2*

The Australian Centre for International and Tropical Health, a Joint Program of the Queensland Institute of Medical Research and the School of Population Health, University of Queensland, Brisbane, Australia,1 Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia,2 World Health Organization—Regional Office for the Western Pacific, Manila, Philippines3

Received 3 August 2006/ Returned for modification 7 September 2006/ Accepted 22 September 2006

Malaria-specific rapid diagnostic tests (RDTs) targeting aldolase show highly variable sensitivities. We assessed diversity in Plasmodium falciparum and P. vivax aldolases by sequencing the coding genes from parasites of various origins. The results show that aldolases are highly conserved, indicating that antigenic diversity is not a cause of variable RDT sensitivity.

* Corresponding author. Mailing address: Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia. Phone: 61-7-3332 4834. Fax: 71-7-3332 4800. E-mail: qin.cheng{at}defence.gov.au.

{triangledown} Published ahead of print on 4 October 2006.

Journal of Clinical Microbiology, December 2006, p. 4547-4549, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.01611-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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