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Journal of Clinical Microbiology, December 2006, p. 4550-4552, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.01542-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Monitoring of Stool Microbiota in Subjects with Diarrhea Indicates Distortions in Composition

Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland,¹ Enteric Diseases Epidemiology Branch, Division of Foodborne, Bacterial, and Mycotic Diseases, National Center for Zoonotic, Vectorborne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta Georgia,² Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland³

Received 25 July 2006/ Returned for modification 13 September 2006/ Accepted 27 September 2006

We utilized denaturing gradient gel electrophoresis profiling to survey stool microbiota in 175 persons with diarrhea and 113 asymptomatic persons in a diarrhea surveillance study. Compared with healthy controls, the microbiota profiles in diarrhea cases more frequently exhibited decreased diversity and strong bands indicating the overgrowth of selected bacteria or bacterial groups.

Published ahead of print on 4 October 2006.