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Journal of Clinical Microbiology, December 2006, p. 4559-4560, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.01440-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Combined Hepatitis C Virus (HCV) Antigen-Antibody Detection Assay Does Not Improve Diagnosis for Seronegative Individuals with Occult HCV Infection{triangledown}

Juan A. Quiroga, Inmaculada Castillo, Margarita Pardo, Elena Rodríguez-Iñigo, and Vicente Carreño*

Fundación para el Estudio de las Hepatitis Virales, Madrid, Spain

Received 12 July 2006/ Returned for modification 22 August 2006/ Accepted 26 September 2006

A combined hepatitis C virus (HCV) antigen-antibody assay was evaluated for 115 seronegative individuals with occult HCV infection. The assay was reactive in one patient and negative to weakly reactive in three others (all four gave indeterminate results by supplemental assay) but failed to detect HCV in the remaining patients. Despite increased sensitivity the combined assay does not improve serodiagnosis of occult HCV infection.

* Corresponding author. Mailing address: Fundación para el Estudio de las Hepatitis Virales, Guzmán el Bueno 72, 28015 Madrid, Spain. Phone: 34-91.544.6013. Fax: 34-91.544.9228. E-mail: fehvhpa{at}fehv.org.

{triangledown} Published ahead of print on 4 October 2006.

Journal of Clinical Microbiology, December 2006, p. 4559-4560, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.01440-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Quiroga, J. A., Castillo, I., Bartolome, J., Carreno, V. (2007). Serum Immunoglobulin G Antibodies to the GOR Autoepitope Are Present in Patients with Occult Hepatitis C Virus (HCV) Infection despite Lack of HCV-Specific Antibodies. CVI 14: 1302-1306 [Abstract] [Full Text]  


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