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Journal of Clinical Microbiology, December 2006, p. 4593-4595, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.00621-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Feasibility of Freeze-Dried Sera for Serological and Molecular Biological Detection of Hepatitis B and C Viruses{triangledown}

Waka Ohishi,1* Saeko Fujiwara,1 Gen Suzuki,1 Takeshi Kishi,1 Misae Sora,1 Shinsuke Matsuura,1 Masayuki Hakoda,1 Yoshimi Tatsukawa,1 Michiko Yamada,1 and Kazuaki Chayama2

Department of Clinical Studies, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima, 732-0815, Japan,1 Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan2

Received 22 March 2006/ Returned for modification 20 August 2006/ Accepted 30 September 2006

We compared hepatitis B virus (HBV) surface antigen, anti-hepatitis C virus (HCV) antibody, and HCV RNA quantification in frozen and freeze-dried serum samples to assess the usefulness of freeze-dried sera for detection of HBV and HCV. The results indicated that freeze-dried sera as well as frozen sera can be useful for serological and molecular biological analyses of HBV and HCV.

* Corresponding author. Mailing address: Department of Clinical Studies, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima, 732-0815, Japan. Phone: 81-82-261-3131. Fax: 81-82-261-3259. E-mail: nwaka{at}rerf.or.jp.

{triangledown} Published ahead of print on 11 October 2006.

Journal of Clinical Microbiology, December 2006, p. 4593-4595, Vol. 44, No. 12
0095-1137/06/$08.00+0     doi:10.1128/JCM.00621-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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