This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hernandez, B. Y. Articles by Ning, L. Search for Related Content PubMed PubMed Citation Articles by Hernandez, B. Y. Articles by Ning, L.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, February 2006, p. 513-517, Vol. 44, No. 2
0095-1137/06/$08.00+0     doi:10.1128/JCM.44.2.513-517.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Comparison of Physician- and Self-Collected Genital Specimens for Detection of Human Papillomavirus in Men

Cancer Research Center of Hawaii,¹ University Health Services, University of Hawaii, Honolulu, Hawaii²

Received 13 October 2005/ Returned for modification 23 November 2005/ Accepted 29 November 2005

There is currently no consensus regarding the most appropriate methods of sampling for the detection of genital human papillomavirus (HPV) in men. We employed a recently developed collection method involving abrasion and moistened swabbing of the genital skin surface for the detection of HPV in a cohort of 136 university-affiliated males in Hawaii. Genital specimens collected by physicians using this method were compared with self-collected specimens from the same individuals obtained 24 h later. Self-collected specimens yielded a greater proportion of sufficient specimens than physician-collected specimens. HPV detection was comparable in physician- and self-collected specimens; detection was highest in the penile shaft (51.2% and 51.5%, respectively, P = 0.96), followed by the scrotum (41.2% and 46.2%, P = 0.43), the glans/coronal sulcus (31.9% and 33.1%, P = 0.84), and the foreskin (33.3% and 28.6%, P = 0.74). Site-specific agreement in HPV detection between paired physician- and self-collected samples ranged from 67.2% (kappa = 0.34) for the penile shaft to 95.0% (kappa = 0.89) for the foreskin. There was a high degree of concordance in HPV genotypes in HPV-positive pairs. The most common type was HPV type 84, which comprised approximately 15% of the specimens. The emery paper-swab method offers an efficient sampling method for genital HPV DNA detection in men that could be used both within and outside of the clinical setting.

This article has been cited by other articles:

• Giuliano, A. R., Lazcano-Ponce, E., Villa, L. L., Flores, R., Salmeron, J., Lee, J.-H., Papenfuss, M. R., Abrahamsen, M., Jolles, E., Nielson, C. M., Baggio, M. L., Silva, R., Quiterio, M. (2008). The Human Papillomavirus Infection in Men Study: Human Papillomavirus Prevalence and Type Distribution among Men Residing in Brazil, Mexico, and the United States. Cancer Epidemiol. Biomarkers Prev. 17: 2036-2043 [Abstract] [Full Text]  
• De Alba, I., Anton-Culver, H., Hubbell, F. A., Ziogas, A., Hess, J. R., Bracho, A., Arias, C., Manetta, A. (2008). Self-Sampling for Human Papillomavirus in a Community Setting: Feasibility in Hispanic Women. Cancer Epidemiol. Biomarkers Prev. 17: 2163-2168 [Abstract] [Full Text]  
• Nielson, C. M., Flores, R., Harris, R. B., Abrahamsen, M., Papenfuss, M. R., Dunne, E. F., Markowitz, L. E., Giuliano, A. R. (2007). Human Papillomavirus Prevalence and Type Distribution in Male Anogenital Sites and Semen. Cancer Epidemiol. Biomarkers Prev. 16: 1107-1114 [Abstract] [Full Text]